I am not terribly thrilled that Marvel is going the "Multiverse" route with their films. The need to make sure that the earlier Spider-Man movies are a part of the Marvel Cinematic Universe is dragging us backwards rather than taking us forward by cutting them loose. Will it be nice to see Alfred Molina as Doc Ock again? Sure. But at the expense of miring the MCU with the silly idea that Peter Parker looks completely different in the different universes? It makes no sense.
But here we go anyway...
In addition to Alfred Molina, we're definitely getting Willen DaFoe as Green Goblin and Jamie Foxx as Electro. And it looks like we're getting Rhys Ifans as The Lizard and Thomas Haden Church as Sandman... though those could just be CGI additions with no connection to the actual actors.
But it's like... why?
Why not create new versions of these characters that are closely tied to what Marvel Studios is doing now? Does this mean that these characters will never appear in the MCU proper because they are from a different universe? That doesn't seem too smart.
It seems likely all of this is to keep Sony happy, since they have the Spider-Man movie rights tied up and, technically, the character is on-loan to Marvel. The Multiverse allows them to have Spider-Man back for their Venom movies and such while still allowing Spider-Man to move forward with Marvel Studio films. It's a profitable double-dip. Assuming Tom Holland wants to continue on. Though this could also all be a set-up to give us Miles Morales Spider-Man.
They really should have let DC Comics hang on to this bad idea in their The Flash movie and kept moving forward with the success they had been having.
Oh well. Dr. Strange looks to be having a great time in the movie, so perhaps that will be compensation for what feels like a big blunder. But who knows? Maybe Marvel has figured it all out so that it's actually a good thing.